Synthesis and Structure–Activity Relationship of Palmatine Derivatives as a Novel Class of Antibacterial Agents against <i>Helicobacter pylori</i>

Synthesis and Structure–Activity Relationship of Palmatine Derivatives as a Novel Class of Antibacterial Agents against <i>Helicobacter pylori</i>

Taking palmatine (PMT) as the lead, 20 new PMT derivatives were synthesized and examined for their antibacterial activities against six tested metronidazole (MTZ)-resistant <i>Helicobacter pylori</i> (<i>H. pylori</i>) strains. The structure&#8722;activity relationship (S...

Full description

Bibliographic Details
Main Authors: Tianyun Fan, Xixi Guo, Qingxuan Zeng, Wei Wei, Xuefu You, Jing Pang, Yanxiang Wang, Danqing Song
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Molecules
Subjects:
<i>helicobacter pylori</i>
palmatine
synthesis
structure–activity relationship
urease
Online Access:https://www.mdpi.com/1420-3049/25/6/1352

Internet

https://www.mdpi.com/1420-3049/25/6/1352

Similar Items