Merlin status regulates p75NTR expression and apoptotic signaling in Schwann cells following nerve injury

Merlin status regulates p75NTR expression and apoptotic signaling in Schwann cells following nerve injury

After nerve injury, Schwann cells (SCs) dedifferentiate, proliferate, and support axon regrowth. If axons fail to regenerate, denervated SCs eventually undergo apoptosis due, in part, to increased expression of the low-affinity neurotrophin receptor, p75NTR. Merlin is the protein product of the NF2...

Full description

Bibliographic Details
Main Authors: Iram Ahmad, Augusta Fernando, Richard Gurgel, J. Jason Clark, Linjing Xu, Marlan R. Hansen
Format: Article
Language:English
Published: Elsevier 2015-10-01
Series:Neurobiology of Disease
Subjects:
Cell death
Schwann cells
Receptor
Nerve growth factor
Neurofibromatosis type 2
Axotomy
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996115002107

Internet

http://www.sciencedirect.com/science/article/pii/S0969996115002107

Similar Items