CD73 blockade enhances the local and abscopal effects of radiotherapy in a murine rectal cancer model

CD73 blockade enhances the local and abscopal effects of radiotherapy in a murine rectal cancer model

Abstract Background Anti-tumor effects of radiation therapy (RT) largely depend on host immune function. Adenosine with its strong immunosuppressive properties is an important immune checkpoint molecule. Method We examined how intra-tumoral adenosine levels modify anti-tumor effects of RT in a murin...

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Bibliographic Details
Main Authors: Hidenori Tsukui, Hisanaga Horie, Koji Koinuma, Hideyuki Ohzawa, Yasunaru Sakuma, Yoshinori Hosoya, Hironori Yamaguchi, Kotaro Yoshimura, Alan Kawarai Lefor, Naohiro Sata, Joji Kitayama
Format: Article
Language:English
Published: BMC 2020-05-01
Series:BMC Cancer
Subjects:
Abscopal effect
Adenosine
CD73
Radiation
Rectal cancer
Online Access:http://link.springer.com/article/10.1186/s12885-020-06893-3

Internet

http://link.springer.com/article/10.1186/s12885-020-06893-3

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