Increased Polyubiquitination and Proteasomal Degradation of a Munc18-1 Disease-Linked Mutant Causes Temperature-Sensitive Defect in Exocytosis

Increased Polyubiquitination and Proteasomal Degradation of a Munc18-1 Disease-Linked Mutant Causes Temperature-Sensitive Defect in Exocytosis

Summary: Munc18-1 is a critical component of the core machinery controlling neuroexocytosis. Recently, mutations in Munc18-1 leading to the development of early infantile epileptic encephalopathy have been discovered. However, which degradative pathway controls Munc18-1 levels and how it impacts on...

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Bibliographic Details
Main Authors: Sally Martin, Andreas Papadopulos, Vanesa M. Tomatis, Emma Sierecki, Nancy T. Malintan, Rachel S. Gormal, Nichole Giles, Wayne A. Johnston, Kirill Alexandrov, Yann Gambin, Brett M. Collins, Frederic A. Meunier
Format: Article
Language:English
Published: Elsevier 2014-10-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124714007359

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http://www.sciencedirect.com/science/article/pii/S2211124714007359

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