Epoxyazadiradione suppresses breast tumor growth through mitochondrial depolarization and caspase-dependent apoptosis by targeting PI3K/Akt pathway

Epoxyazadiradione suppresses breast tumor growth through mitochondrial depolarization and caspase-dependent apoptosis by targeting PI3K/Akt pathway

Abstract Background Breast cancer is one of the most commonly diagnosed invasive cancers among women around the world. Among several subtypes, triple negative breast cancer (TNBC) is highly aggressive and chemoresistant. Treatment of TNBC patients has been challenging due to heterogeneity and devoid...

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Bibliographic Details
Main Authors: Dhiraj Kumar, Saikat Haldar, Mahadeo Gorain, Santosh Kumar, Fayaj A. Mulani, Amit S. Yadav, Lucio Miele, Hirekodathakallu V. Thulasiram, Gopal C. Kundu
Format: Article
Language:English
Published: BMC 2018-01-01
Series:BMC Cancer
Subjects:
Breast cancer
Apoptosis
PI3K
Metastasis
Angiogenesis
Limonoids
Online Access:http://link.springer.com/article/10.1186/s12885-017-3876-2

Internet

http://link.springer.com/article/10.1186/s12885-017-3876-2

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