Melatonin Activates Endoplasmic Reticulum Stress and Apoptosis in Rats with Diethylnitrosamine-Induced Hepatocarcinogenesis.

Hepatocellular carcinoma (HCC) is one of the most lethal human cancers worldwide because of its high incidence, its metastatic potential and the low efficacy of conventional treatment. Inactivation of apoptosis is implicated in tumour progression and chemotherapy resistance, and has been linked to t...

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Bibliographic Details
Main Authors: Andrea Janz Moreira, Raquel Ordoñez, Carlos Thadeu Cerski, Jaqueline Nascimento Picada, Andrés García-Palomo, Norma Possa Marroni, Jose L Mauriz, Javier González-Gallego
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4684373?pdf=render