P2X7 Receptors and TMEM16 Channels Are Functionally Coupled with Implications for Macropore Formation and Current Facilitation

P2X7 Receptors and TMEM16 Channels Are Functionally Coupled with Implications for Macropore Formation and Current Facilitation

P2X7 receptors (P2X7) are cationic channels involved in many diseases. Following their activation by extracellular ATP, distinct signaling pathways are triggered, which lead to various physiological responses such as the secretion of pro-inflammatory cytokines or the modulation of cell death. P2X7 a...

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Bibliographic Details
Main Authors: Kate Dunning, Adeline Martz, Francisco Andrés Peralta, Federico Cevoli, Eric Boué-Grabot, Vincent Compan, Fanny Gautherat, Patrick Wolf, Thierry Chataigneau, Thomas Grutter
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
P2X7
anoctamin
ATP sensitization
cell permeabilization
purinergic receptor
ion channel
Online Access:https://www.mdpi.com/1422-0067/22/12/6542

Internet

https://www.mdpi.com/1422-0067/22/12/6542

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