Optimization and development of insulin nanoparticles by new thiolated chitosan derivative with ionic gelation method using a model-based methodology

Insulin therapy has been the best choice for the clinical management of diabetes mellitus. The current insulin therapy is via subcutaneous injection, which often fails to mimic the glucose homeostasis that occurs in normal individuals. Oral delivery is the most convenient administration route. Howev...

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Bibliographic Details
Main Authors: Zahra Mahdizadeh Barzoki, Zahra Emam-Djomeh, Morteza Rafiee-Tehrani, Elaheh Mortazavian, Ali Akbar Moosavi Movahedi
Format: Article
Language:English
Published: University of Tehran 2019-06-01
Series:Journal of Food and Bioprocess Engineering
Subjects:
Online Access:https://jfabe.ut.ac.ir/article_73075_dac7632abdef522b0aecf29bd9b9c6d4.pdf