Cardiac and Vascular α₁-Adrenoceptors in Congestive Heart Failure: A Systematic Review

• Main Authors: Gizem Kaykı-Mutlu, Olga Papazisi, Meindert Palmen, A. H. Jan Danser, Martin C. Michel, Ebru Arioglu-Inan
• Format: Article
• Language: English
• Published: MDPI AG 2020-11-01
• Series: Cells
• Subjects: α₁-adrenoceptors; cardiomyocyte; blood vessel; heart failure
• Online Access: https://www.mdpi.com/2073-4409/9/11/2412

As heart failure (HF) is a devastating health problem worldwide, a better understanding and the development of more effective therapeutic approaches are required. HF is characterized by sympathetic system activation which stimulates α- and β-adrenoceptors (ARs). The exposure of the cardiovascular system to the increased locally released and circulating levels of catecholamines leads to a well-described downregulation and desensitization of β-ARs. However, information on the role of α-AR is limited. We have performed a systematic literature review examining the role of both cardiac and vascular α₁-ARs in HF using 5 databases for our search. All three α₁-AR subtypes (α_1A, α_1B and α_1D) are expressed in human and animal hearts and blood vessels in a tissue-dependent manner. We summarize the changes observed in HF regarding the density, signaling and responses of α₁-ARs. Conflicting findings arise from different studies concerning the influence that HF has on α₁-AR expression and function; in contrast to β-ARs there is no consistent evidence for down-regulation or desensitization of cardiac or vascular α₁-ARs. Whether α₁-ARs are a therapeutic target in HF remains a matter of debate.