Acute inhibition of neurosteroid estrogen synthesis suppresses status epilepticus in an animal model

Status epilepticus (SE) is a common neurological emergency for which new treatments are needed. In vitro studies suggest a novel approach to controlling seizures in SE: acute inhibition of estrogen synthesis in the brain. Here, we show in rats that systemic administration of an aromatase (estrogen s...

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Bibliographic Details
Main Authors: Satoru M Sato, Catherine S Woolley
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-04-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/12917