Lead-Induced Atypical Parkinsonism in Rats: Behavioral, Electrophysiological, and Neurochemical Evidence for a Role of Noradrenaline Depletion

Background: Lead neurotoxicity is a major health problem known as a risk factor for neurodegenerative diseases, including the manifestation of parkinsonism-like disorder. While lead is known to preferentially accumulate in basal ganglia, the mechanisms underlying behavioral disorders remain unknown....

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Bibliographic Details
Main Authors: Mariam Sabbar, Claire Delaville, Philippe De Deurwaerdère, Nouria Lakhdar-Ghazal, Abdelhamid Benazzouz
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Neuroscience
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Online Access:http://journal.frontiersin.org/article/10.3389/fnins.2018.00173/full