A Mixture of Polyunsaturated Fatty Acids ω-3 and ω-6 Reduces Melanoma Growth by Inhibiting Inflammatory Mediators in the Murine Tumor Microenvironment

A Mixture of Polyunsaturated Fatty Acids ω-3 and ω-6 Reduces Melanoma Growth by Inhibiting Inflammatory Mediators in the Murine Tumor Microenvironment

Background: Although it has been previously demonstrated that acute inflammation can promote the tumor growth of a sub-tumorigenic dose of melanoma cells through of 5-lipoxygenase inflammatory pathway and its product leukotriene B<sub>4,</sub> and also that the peritumoral treatment with...

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Bibliographic Details
Main Authors: Ewin B. Almeida, Karina P.H. Silva, Vitoria Paixão, Jônatas B. do Amaral, Marcelo Rossi, Roberta A. Xavier-Navarro, Karina V. Barros, Vera L.F. Silveira, Rodolfo P. Vieira, Luis V.F. Oliveira, Elizabeth C. Perez, Miriam G. Jasiulionis, André L.L. Bachi
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:International Journal of Molecular Sciences
Subjects:
cyclooxygenase (COX)
lipoxygenase (LOX)
acute inflammation
leukotrienes
prostaglandins
cytokines
melanoma
Online Access:https://www.mdpi.com/1422-0067/20/15/3765

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https://www.mdpi.com/1422-0067/20/15/3765

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