Gene disruption of Plasmodium falciparum p52 results in attenuation of malaria liver stage development in cultured primary human hepatocytes.

Gene disruption of Plasmodium falciparum p52 results in attenuation of malaria liver stage development in cultured primary human hepatocytes.

Difficulties with inducing sterile and long lasting protective immunity against malaria with subunit vaccines has renewed interest in vaccinations with attenuated Plasmodium parasites. Immunizations with sporozoites that are attenuated by radiation (RAS) can induce strong protective immunity both in...

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Bibliographic Details
Main Authors: Ben C L van Schaijk, Chris J Janse, Geert-Jan van Gemert, Melissa R van Dijk, Audrey Gego, Jean-Francois Franetich, Marga van de Vegte-Bolmer, Samir Yalaoui, Olivier Silvie, Stephen L Hoffman, Andrew P Waters, Dominique Mazier, Robert W Sauerwein, Shahid M Khan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2568858?pdf=render

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http://europepmc.org/articles/PMC2568858?pdf=render

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