Isx9 Regulates Calbindin D28K Expression in Pancreatic β Cells and Promotes β Cell Survival and Function

Isx9 Regulates Calbindin D28K Expression in Pancreatic β Cells and Promotes β Cell Survival and Function

Pancreatic β-cell dysfunction and death contribute to the onset of diabetes, and novel strategies of β-cell function and survival under diabetogenic conditions need to be explored. We previously demonstrated that Isx9, a small molecule based on the isoxazole scaffold, drives neuroe...

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Bibliographic Details
Main Authors: Julien B. Pujol, Eija Heikkila, Claudia Savoia, Asghar Hajibeigi, Umberto De Marchi, Pavan K. Battiprolu, Orhan K. Öz, El Hadji M. Dioum
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:International Journal of Molecular Sciences
Subjects:
Isx9
apoptosis
calbindin-D28K
calcium homeostasis
inflammation
serum deprivation
calcineurin
NFAT transcription factor
β cell function
Online Access:http://www.mdpi.com/1422-0067/19/9/2542

Internet

http://www.mdpi.com/1422-0067/19/9/2542

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