Quantitative trait locus mapping identifies the Gpnmb gene as a modifier of mouse macrophage lysosome function

Quantitative trait locus mapping identifies the Gpnmb gene as a modifier of mouse macrophage lysosome function

Abstract We have previously shown that the DBA/2J versus AKR/J mouse strain is associated with decreased autophagy-mediated lysosomal hydrolysis of cholesterol esters. Our objective was to determine differences in lysosome function in AKR/J and DBA/2J macrophages, and identify the responsible genes....

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Bibliographic Details
Main Authors: Peggy Robinet, Brian Ritchey, Shuhui Wang Lorkowski, Alexander M. Alzayed, Sophia DeGeorgia, Eve Schodowski, C. Alicia Traughber, Jonathan D. Smith
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-89800-5

Internet

https://doi.org/10.1038/s41598-021-89800-5

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