Post-traumatic administration of the p53 inactivator pifithrin-α oxygen analogue reduces hippocampal neuronal loss and improves cognitive deficits after experimental traumatic brain injury

Post-traumatic administration of the p53 inactivator pifithrin-α oxygen analogue reduces hippocampal neuronal loss and improves cognitive deficits after experimental traumatic brain injury

Traumatic brain injury (TBI) is a major cause of death and disability worldwide. Neuronal apoptosis in the hippocampus has been detected after TBI. The hippocampal dysfunction may result in cognitive deficits in learning, memory, and spatial information processing. Our previous studies demonstrated...

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Bibliographic Details
Main Authors: Ling-Yu Yang, Nigel H. Greig, Ya-Ni Huang, Tsung-Hsun Hsieh, David Tweedie, Qian-Sheng Yu, Barry J. Hoffer, Yu Luo, Yu-Chieh Kao, Jia-Yi Wang
Format: Article
Language:English
Published: Elsevier 2016-12-01
Series:Neurobiology of Disease
Subjects:
Traumatic brain injury (TBI)
p53
Pifithrin-α (PFT-α)
PFT-α oxygen analogue (PFT-α (O))
Apoptosis
Motor and cognitive deficits
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996116302042

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http://www.sciencedirect.com/science/article/pii/S0969996116302042

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