Constitutively active GSK3β as a means to bolster dendritic cell functionality in the face of tumour-mediated immune suppression

Constitutively active GSK3β as a means to bolster dendritic cell functionality in the face of tumour-mediated immune suppression

In patients with cancer, the functionality of Dendritic Cells (DC) is hampered by high levels of tumor-derived suppressive cytokines, which interfere with DC development and maturation. Poor DC development can limit the efficacy of immune checkpoint blockade and in vivo vaccination approaches. Inter...

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Bibliographic Details
Main Authors: Marta López González, Dinja Oosterhoff, Jelle J. Lindenberg, Ioanna Milenova, Sinead M. Lougheed, Tania Martiáñez, Henk Dekker, Dafne Carolina Alves Quixabeira, Basav Hangalapura, Jos Joore, Sander R. Piersma, Victor Cervera-Carrascon, Joao Manuel Santos, Rik J. Scheper, Henk M.W. Verheul, Connie R. Jiménez, Rieneke Van De Ven, Akseli Hemminki, Victor W. Van Beusechem, Tanja D. De Gruijl
Format: Article
Language:English
Published: Taylor & Francis Group 2019-10-01
Series:OncoImmunology
Subjects:
dendritic cell
differentiation
maturation
il-10
gsk3β
kinase profiling
tumor microenvironment
Online Access:http://dx.doi.org/10.1080/2162402X.2019.1631119

Internet

http://dx.doi.org/10.1080/2162402X.2019.1631119

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