The KrasG12D;Trp53fl/fl murine model of undifferentiated pleomorphic sarcoma is macrophage dense, lymphocyte poor, and resistant to immune checkpoint blockade.

The KrasG12D;Trp53fl/fl murine model of undifferentiated pleomorphic sarcoma is macrophage dense, lymphocyte poor, and resistant to immune checkpoint blockade.

Sarcomas are rare, difficult to treat, mesenchymal lineage tumours that affect children and adults. Immunologically-based therapies have improved outcomes for numerous adult cancers, however, these therapeutic strategies have been minimally effective in sarcoma so far. Clinically relevant, immunolog...

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Bibliographic Details
Main Authors: Karys M Hildebrand, Arvind K Singla, Reid McNeil, Kayla L Marritt, Kurt N Hildebrand, Franz Zemp, Jahanara Rajwani, Doha Itani, Pinaki Bose, Douglas J Mahoney, Frank R Jirik, Michael J Monument
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0253864

Internet

https://doi.org/10.1371/journal.pone.0253864

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