MicroRNA-199a Inhibits Cellular Autophagy and Downregulates IFN-β Expression by Targeting TBK1 in Mycobacterium bovis Infected Cells

MicroRNA-199a Inhibits Cellular Autophagy and Downregulates IFN-β Expression by Targeting TBK1 in Mycobacterium bovis Infected Cells

The mechanism by which microRNAs (miRNAs) modulate innate immunity and autophagy has not been fully elucidated in Mycobacterium bovis (M. bovis) infections. In this study, we identified that miR-199a inhibited key innate immune responses and autophagy in murine macrophages infected with M. bovis. Us...

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Bibliographic Details
Main Authors: Jie Wang, Tariq Hussain, Ruichao Yue, Yi Liao, Qiang Li, Jiao Yao, Yinjuan Song, Xin Sun, Nan Wang, Lei Xu, Srinand Sreevatsan, Deming Zhao, Xiangmei Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
M. bovis
immunity
autophagy
IFN-β
microRNA
TBK1
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2018.00238/full

Internet

https://www.frontiersin.org/article/10.3389/fcimb.2018.00238/full

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