Aberrant Hypermethylation-Mediated Suppression of PYCARD Is Extremely Frequent in Prostate Cancer with Gleason Score ≥ 7

Aberrant Hypermethylation-Mediated Suppression of PYCARD Is Extremely Frequent in Prostate Cancer with Gleason Score ≥ 7

Epigenetic gene silencing by aberrant DNA methylation leads to loss of key cellular pathways in tumorigenesis. In order to analyze the effects of DNA methylation on prostate cancer, we established LNCaP-derived human prostate cancer cells that can pharmacologically induce global reactivation of hype...

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Bibliographic Details
Main Authors: Toshiya Miyauchi, Masahiro Takahashi, Koji Mitsuzuka, Yuriko Saiki, Teppei Okubo, Paula M. Vertino, Akiteru Goto, Yoichi Arai, Akira Horii, Shinichi Fukushige
Format: Article
Language:English
Published: Hindawi Limited 2021-01-01
Series:Disease Markers
Online Access:http://dx.doi.org/10.1155/2021/8858905

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http://dx.doi.org/10.1155/2021/8858905

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