Epidemiology, Clinical Features and Prognostic Factors of Pediatric SARS-CoV-2 Infection: Results From an Italian Multicenter Study
Background: Many aspects of SARS-CoV-2 infection in children and adolescents remain unclear and optimal treatment is debated. The objective of our study was to investigate epidemiological, clinical and therapeutic characteristics of pediatric SARS-CoV-2 infection, focusing on risk factors for compli...
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Format: | Article |
Language: | English |
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Frontiers Media S.A.
2021-03-01
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Series: | Frontiers in Pediatrics |
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Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2021.649358/full |
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English |
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DOAJ |
author |
Silvia Garazzino Andrea Lo Vecchio Luca Pierantoni Francesca Ippolita Calò Carducci Federico Marchetti Antonella Meini Elio Castagnola Gianluca Vergine Daniele Donà Samantha Bosis Icilio Dodi Elisabetta Venturini Enrico Felici Roberta Giacchero Marco Denina Luca Pierri Giangiacomo Nicolini Carlotta Montagnani Andrzej Krzysztofiak Sonia Bianchini Caterina Marabotto Pier-Angelo Tovo Giulia Pruccoli Marcello Lanari Alberto Villani Guido Castelli Gattinara The Italian SITIP-SIP Pediatric Infection Study Group Valeria Caldarelli Filippo Maria Salvini Giovanni Corsello Barba Paolo Del Paola Berlese Carlo Agostoni Chiara Ghizzi Vera Quadri Sara Riscassi Ivana Rabbone Carmelina Calitri Luisa Abbagnato Luciana Parola Giuseppe Banderali Ilaria Pacati Simonetta Cherubini Paola Lippi Andrea Guala Rino Agostiniani Salvatore Cazzato Ahmad Kantar Luca Baroero Nadia Rossi Cristina Dalmazzo Laura Panigati Paolo Manzoni Alessandro Vigo Ludovica Fiore Pasquale Comberiati Gianna Battezzati Paola Verna Gianluca Tornese Paola Gianino Luca Bertacca Angelina Vaccaro Giorgio Zavarise Luigi Marchione Paola Gallia Paola Di Filippo Chiara Centenari Alessandra Iacono Alessandro Plebani Marta Ferretti Sara Rizzi Sara Rossin Paola Marchisio Alessandro De Fanti Costantino De Giacomo Giuliana Ferrante Graziano Barera Pajno Roberta Stefano Martelossi Alessia Rocchi Rosa Francavilla Valin Paola Sogno Marco Poeta Piero Valentini Raffaele Papa Anna Maria Magistà Raffaele Badolato Carolina Saffioti Maria Cristina Greco Paola Costenaro Maria Di Pietro Susanna Esposito Giovanni Pieri Maria Valentina Spartà Valentina Maffini Laura Cursi Francesco Nunziata Federica Mignone Claudia Bondone Giacomo Stera Agostina Marolda Lorenzo Fiorica Caterina Sabatini Maria Rita Genovese Cristina Ferrari Luisa Galli |
spellingShingle |
Silvia Garazzino Andrea Lo Vecchio Luca Pierantoni Francesca Ippolita Calò Carducci Federico Marchetti Antonella Meini Elio Castagnola Gianluca Vergine Daniele Donà Samantha Bosis Icilio Dodi Elisabetta Venturini Enrico Felici Roberta Giacchero Marco Denina Luca Pierri Giangiacomo Nicolini Carlotta Montagnani Andrzej Krzysztofiak Sonia Bianchini Caterina Marabotto Pier-Angelo Tovo Giulia Pruccoli Marcello Lanari Alberto Villani Guido Castelli Gattinara The Italian SITIP-SIP Pediatric Infection Study Group Valeria Caldarelli Filippo Maria Salvini Giovanni Corsello Barba Paolo Del Paola Berlese Carlo Agostoni Chiara Ghizzi Vera Quadri Sara Riscassi Ivana Rabbone Carmelina Calitri Luisa Abbagnato Luciana Parola Giuseppe Banderali Ilaria Pacati Simonetta Cherubini Paola Lippi Andrea Guala Rino Agostiniani Salvatore Cazzato Ahmad Kantar Luca Baroero Nadia Rossi Cristina Dalmazzo Laura Panigati Paolo Manzoni Alessandro Vigo Ludovica Fiore Pasquale Comberiati Gianna Battezzati Paola Verna Gianluca Tornese Paola Gianino Luca Bertacca Angelina Vaccaro Giorgio Zavarise Luigi Marchione Paola Gallia Paola Di Filippo Chiara Centenari Alessandra Iacono Alessandro Plebani Marta Ferretti Sara Rizzi Sara Rossin Paola Marchisio Alessandro De Fanti Costantino De Giacomo Giuliana Ferrante Graziano Barera Pajno Roberta Stefano Martelossi Alessia Rocchi Rosa Francavilla Valin Paola Sogno Marco Poeta Piero Valentini Raffaele Papa Anna Maria Magistà Raffaele Badolato Carolina Saffioti Maria Cristina Greco Paola Costenaro Maria Di Pietro Susanna Esposito Giovanni Pieri Maria Valentina Spartà Valentina Maffini Laura Cursi Francesco Nunziata Federica Mignone Claudia Bondone Giacomo Stera Agostina Marolda Lorenzo Fiorica Caterina Sabatini Maria Rita Genovese Cristina Ferrari Luisa Galli Epidemiology, Clinical Features and Prognostic Factors of Pediatric SARS-CoV-2 Infection: Results From an Italian Multicenter Study Frontiers in Pediatrics SARS-CoV-2 infection children multisystem inflammatory syndrome MIS-C COVID-19 |
author_facet |
Silvia Garazzino Andrea Lo Vecchio Luca Pierantoni Francesca Ippolita Calò Carducci Federico Marchetti Antonella Meini Elio Castagnola Gianluca Vergine Daniele Donà Samantha Bosis Icilio Dodi Elisabetta Venturini Enrico Felici Roberta Giacchero Marco Denina Luca Pierri Giangiacomo Nicolini Carlotta Montagnani Andrzej Krzysztofiak Sonia Bianchini Caterina Marabotto Pier-Angelo Tovo Giulia Pruccoli Marcello Lanari Alberto Villani Guido Castelli Gattinara The Italian SITIP-SIP Pediatric Infection Study Group Valeria Caldarelli Filippo Maria Salvini Giovanni Corsello Barba Paolo Del Paola Berlese Carlo Agostoni Chiara Ghizzi Vera Quadri Sara Riscassi Ivana Rabbone Carmelina Calitri Luisa Abbagnato Luciana Parola Giuseppe Banderali Ilaria Pacati Simonetta Cherubini Paola Lippi Andrea Guala Rino Agostiniani Salvatore Cazzato Ahmad Kantar Luca Baroero Nadia Rossi Cristina Dalmazzo Laura Panigati Paolo Manzoni Alessandro Vigo Ludovica Fiore Pasquale Comberiati Gianna Battezzati Paola Verna Gianluca Tornese Paola Gianino Luca Bertacca Angelina Vaccaro Giorgio Zavarise Luigi Marchione Paola Gallia Paola Di Filippo Chiara Centenari Alessandra Iacono Alessandro Plebani Marta Ferretti Sara Rizzi Sara Rossin Paola Marchisio Alessandro De Fanti Costantino De Giacomo Giuliana Ferrante Graziano Barera Pajno Roberta Stefano Martelossi Alessia Rocchi Rosa Francavilla Valin Paola Sogno Marco Poeta Piero Valentini Raffaele Papa Anna Maria Magistà Raffaele Badolato Carolina Saffioti Maria Cristina Greco Paola Costenaro Maria Di Pietro Susanna Esposito Giovanni Pieri Maria Valentina Spartà Valentina Maffini Laura Cursi Francesco Nunziata Federica Mignone Claudia Bondone Giacomo Stera Agostina Marolda Lorenzo Fiorica Caterina Sabatini Maria Rita Genovese Cristina Ferrari Luisa Galli |
author_sort |
Silvia Garazzino |
title |
Epidemiology, Clinical Features and Prognostic Factors of Pediatric SARS-CoV-2 Infection: Results From an Italian Multicenter Study |
title_short |
Epidemiology, Clinical Features and Prognostic Factors of Pediatric SARS-CoV-2 Infection: Results From an Italian Multicenter Study |
title_full |
Epidemiology, Clinical Features and Prognostic Factors of Pediatric SARS-CoV-2 Infection: Results From an Italian Multicenter Study |
title_fullStr |
Epidemiology, Clinical Features and Prognostic Factors of Pediatric SARS-CoV-2 Infection: Results From an Italian Multicenter Study |
title_full_unstemmed |
Epidemiology, Clinical Features and Prognostic Factors of Pediatric SARS-CoV-2 Infection: Results From an Italian Multicenter Study |
title_sort |
epidemiology, clinical features and prognostic factors of pediatric sars-cov-2 infection: results from an italian multicenter study |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Pediatrics |
issn |
2296-2360 |
publishDate |
2021-03-01 |
description |
Background: Many aspects of SARS-CoV-2 infection in children and adolescents remain unclear and optimal treatment is debated. The objective of our study was to investigate epidemiological, clinical and therapeutic characteristics of pediatric SARS-CoV-2 infection, focusing on risk factors for complicated and critical disease.Methods: The present multicenter Italian study was promoted by the Italian Society of Pediatric Infectious Diseases, involving both pediatric hospitals and general pediatricians/family doctors. All subjects under 18 years of age with documented SARS-CoV-2 infection and referred to the coordinating center were enrolled from March 2020.Results: As of 15 September 2020, 759 children were enrolled (median age 7.2 years, IQR 1.4; 12.4). Among the 688 symptomatic children, fever was the most common symptom (81.9%). Barely 47% of children were hospitalized for COVID-19. Age was inversely related to hospital admission (p < 0.01) and linearly to length of stay (p = 0.014). One hundred forty-nine children (19.6%) developed complications. Comorbidities were risk factors for complications (p < 0.001). Viral coinfections, underlying clinical conditions, age 5–9 years and lymphopenia were statistically related to ICU admission (p < 0.05).Conclusions: Complications of COVID-19 in children are related to comorbidities and increase with age. Viral co-infections are additional risk factors for disease progression and multisystem inflammatory syndrome temporarily related to COVID-19 (MIS-C) for ICU admission. |
topic |
SARS-CoV-2 infection children multisystem inflammatory syndrome MIS-C COVID-19 |
url |
https://www.frontiersin.org/articles/10.3389/fped.2021.649358/full |
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doaj-2ec8e367cab847efa6b8f95c3ad14d342021-03-16T05:37:33ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602021-03-01910.3389/fped.2021.649358649358Epidemiology, Clinical Features and Prognostic Factors of Pediatric SARS-CoV-2 Infection: Results From an Italian Multicenter StudySilvia Garazzino0Andrea Lo Vecchio1Luca Pierantoni2Francesca Ippolita Calò Carducci3Federico Marchetti4Antonella Meini5Elio Castagnola6Gianluca Vergine7Daniele Donà8Samantha Bosis9Icilio Dodi10Elisabetta Venturini11Enrico Felici12Roberta Giacchero13Marco Denina14Luca Pierri15Giangiacomo Nicolini16Carlotta Montagnani17Andrzej Krzysztofiak18Sonia Bianchini19Caterina Marabotto20Pier-Angelo Tovo21Giulia Pruccoli22Marcello Lanari23Alberto Villani24Guido Castelli Gattinara25The Italian SITIP-SIP Pediatric Infection Study GroupValeria CaldarelliFilippo Maria SalviniGiovanni CorselloBarba Paolo DelPaola BerleseCarlo AgostoniChiara GhizziVera QuadriSara RiscassiIvana RabboneCarmelina CalitriLuisa AbbagnatoLuciana ParolaGiuseppe BanderaliIlaria PacatiSimonetta CherubiniPaola LippiAndrea GualaRino AgostinianiSalvatore CazzatoAhmad KantarLuca BaroeroNadia RossiCristina DalmazzoLaura PanigatiPaolo ManzoniAlessandro VigoLudovica FiorePasquale ComberiatiGianna BattezzatiPaola VernaGianluca TornesePaola GianinoLuca BertaccaAngelina VaccaroGiorgio ZavariseLuigi MarchionePaola GalliaPaola Di FilippoChiara CentenariAlessandra IaconoAlessandro PlebaniMarta FerrettiSara RizziSara RossinPaola MarchisioAlessandro De FantiCostantino De GiacomoGiuliana FerranteGraziano BareraPajno RobertaStefano MartelossiAlessia RocchiRosa FrancavillaValin Paola SognoMarco PoetaPiero ValentiniRaffaele PapaAnna Maria MagistàRaffaele BadolatoCarolina SaffiotiMaria Cristina GrecoPaola CostenaroMaria Di PietroSusanna EspositoGiovanni PieriMaria Valentina SpartàValentina MaffiniLaura CursiFrancesco NunziataFederica MignoneClaudia BondoneGiacomo SteraAgostina MaroldaLorenzo FioricaCaterina SabatiniMaria Rita GenoveseCristina FerrariLuisa GalliPediatric Infectious Diseases Unit, Regina Margherita Children's Hospital, University of Turin, Turin, ItalySection of Pediatrics, Department of Translational Medical Science, University of Naples Federico II, Naples, ItalyPediatric Emergency Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, ItalyUniversitarian-Hospital Department, Ospedale Bambino Gesù IRCCS, Rome, ItalyDepartment of Pediatrics, Santa Maria delle Croci Hospital, Ravenna, ItalyDepartment of Experimental and Clinical Sciences, Pediatric Clinic, University of Brescia, Brescia, ItalyInfectious Diseases Unit, IRCCS Istituto Giannina Gaslini, Genoa, ItalyUOC Pediatria, Ospedale degli Infermi di Rimini, Rimini, ItalyDivision of Pediatric Infectious Diseases, Department of Women's and Children's Health, University Hospital of Padua, Padua, Italy0Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan, Italy1Emergency and General Pediatric Unit, Pietro Barilla Children's Hospital, Parma, Italy2Infection Disease Unit, Meyer Children's University Hospital, Florence, Italy3Pediatric and Pediatric Emergency Unit, The Children Hospital, AO SS Antonio e Biagio e C. Arrigo, Alessandria, Italy4UOC Pediatria ASST di Lodi, Lodi, ItalyPediatric Infectious Diseases Unit, Regina Margherita Children's Hospital, University of Turin, Turin, ItalySection of Pediatrics, Department of Translational Medical Science, University of Naples Federico II, Naples, Italy5UOC Pediatria, San Martino Hospital, Belluno, Italy2Infection Disease Unit, Meyer Children's University Hospital, Florence, ItalyUniversitarian-Hospital Department, Ospedale Bambino Gesù IRCCS, Rome, Italy6Department of Pediatrics, ASST Santi Paolo e Carlo Hospital, Milan, ItalyUniversitarian-Hospital Department, Ospedale Bambino Gesù IRCCS, Rome, ItalyPediatric Infectious Diseases Unit, Regina Margherita Children's Hospital, University of Turin, Turin, ItalyPediatric Infectious Diseases Unit, Regina Margherita Children's Hospital, University of Turin, Turin, ItalyPediatric Emergency Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, ItalyUniversitarian-Hospital Department, Ospedale Bambino Gesù IRCCS, Rome, ItalyUniversitarian-Hospital Department, Ospedale Bambino Gesù IRCCS, Rome, ItalyBackground: Many aspects of SARS-CoV-2 infection in children and adolescents remain unclear and optimal treatment is debated. The objective of our study was to investigate epidemiological, clinical and therapeutic characteristics of pediatric SARS-CoV-2 infection, focusing on risk factors for complicated and critical disease.Methods: The present multicenter Italian study was promoted by the Italian Society of Pediatric Infectious Diseases, involving both pediatric hospitals and general pediatricians/family doctors. All subjects under 18 years of age with documented SARS-CoV-2 infection and referred to the coordinating center were enrolled from March 2020.Results: As of 15 September 2020, 759 children were enrolled (median age 7.2 years, IQR 1.4; 12.4). Among the 688 symptomatic children, fever was the most common symptom (81.9%). Barely 47% of children were hospitalized for COVID-19. Age was inversely related to hospital admission (p < 0.01) and linearly to length of stay (p = 0.014). One hundred forty-nine children (19.6%) developed complications. Comorbidities were risk factors for complications (p < 0.001). Viral coinfections, underlying clinical conditions, age 5–9 years and lymphopenia were statistically related to ICU admission (p < 0.05).Conclusions: Complications of COVID-19 in children are related to comorbidities and increase with age. Viral co-infections are additional risk factors for disease progression and multisystem inflammatory syndrome temporarily related to COVID-19 (MIS-C) for ICU admission.https://www.frontiersin.org/articles/10.3389/fped.2021.649358/fullSARS-CoV-2 infectionchildrenmultisystem inflammatory syndromeMIS-CCOVID-19 |