The Choroid Plexus Is Permissive for a Preactivated Antigen-Experienced Memory B-Cell Subset in Multiple Sclerosis

The Choroid Plexus Is Permissive for a Preactivated Antigen-Experienced Memory B-Cell Subset in Multiple Sclerosis

The role of B cells in multiple sclerosis (MS) is increasingly recognized. B cells undergo compartmentalized redistribution in blood and cerebrospinal fluid (CSF) during active MS, whereby memory B cells accumulate in the CSF. While B-cell trafficking across the blood–brain barrier has been intensel...

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Bibliographic Details
Main Authors: Jürgen Haas, Henriette Rudolph, Leonardo Costa, Simon Faller, Saskia Libicher, Cornelia Würthwein, Sven Jarius, Hiroshi Ishikawa, Carolin Stump-Guthier, Tobias Tenenbaum, Christian Schwerk, Horst Schroten, Brigitte Wildemann
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Immunology
Subjects:
multiple sclerosis
blood-cerebrospinal fluid barrier
B lymphocytes
transmigration
human
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.618544/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.618544/full

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