Inflammatory Immune Cytokine TNF-α Modulates Ezrin Protein Activation via FAK/RhoA Signaling Pathway in PMVECs Hyperpermeability

Inflammatory Immune Cytokine TNF-α Modulates Ezrin Protein Activation via FAK/RhoA Signaling Pathway in PMVECs Hyperpermeability

Background: One of the important pathogenesis of acute respiratory distress syndrome (ARDS) is the dysfunction of pulmonary microvascular endothelial barrier induced by a hyperinflammatory immune response. However, the potential mechanisms of such an imbalance in pulmonary microvascular endothelial...

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Bibliographic Details
Main Authors: Qun Zhou, Jianjun Jiang, Guanjun Chen, Cheng Qian, Gengyun Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Pharmacology
Subjects:
acute respiratory distress syndrome
inflammatory immune response
endothelial permeability
Ezrin protein
molecular mechanism
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.676817/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.676817/full

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