Exosomal MicroRNA-374b-5p From Tubular Epithelial Cells Promoted M1 Macrophages Activation and Worsened Renal Ischemia/Reperfusion Injury

Exosomal MicroRNA-374b-5p From Tubular Epithelial Cells Promoted M1 Macrophages Activation and Worsened Renal Ischemia/Reperfusion Injury

Tubular epithelial cells (TECs) represent the primary site of renal ischemia/reperfusion injury (RIRI). However, whether the damage of TECs could drive the initiation of inflammation was unclear. Here we investigated the role of the TECs and macrophages during RIRI. Increased expression of inflammat...

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Bibliographic Details
Main Authors: Chenguang Ding, Jin Zheng, Bo Wang, Yang Li, Heli Xiang, Meng Dou, Yuxi Qiao, Puxun Tian, Xiaoming Ding, Wujun Xue
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
renal ischemia/reperfusion injury
tubular epithelial cells
macrophage
exosomes
miR-374b-5p
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2020.587693/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2020.587693/full

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