Orally Administrated Ascorbic Acid Suppresses Neuronal Damage and Modifies Expression of SVCT2 and GLUT1 in the Brain of Diabetic Rats with Cerebral Ischemia-Reperfusion

Orally Administrated Ascorbic Acid Suppresses Neuronal Damage and Modifies Expression of SVCT2 and GLUT1 in the Brain of Diabetic Rats with Cerebral Ischemia-Reperfusion

Diabetes mellitus is known to exacerbate cerebral ischemic injury. In the present study, we investigated antiapoptotic and anti-inflammatory effects of oral supplementation of ascorbic acid (AA) on cerebral injury caused by middle cerebral artery occlusion and reperfusion (MCAO/Re) in rats with stre...

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Bibliographic Details
Main Authors: Naohiro Iwata, Mari Okazaki, Meiyan Xuan, Shinya Kamiuchi, Hirokazu Matsuzaki, Yasuhide Hibino
Format: Article
Language:English
Published: MDPI AG 2014-04-01
Series:Nutrients
Subjects:
ascorbic acid
diabetes mellitus
oxidative stress
apoptosis
proinflammatory
cytokine
sodium-dependent vitamin C transporter 2 (SVCT2)
glucose transporter 1 (GLUT1)
rat
streptozotocin
middle cerebral artery occlusion and reperfusion
Online Access:http://www.mdpi.com/2072-6643/6/4/1554

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http://www.mdpi.com/2072-6643/6/4/1554

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