The major cow milk allergen Bos d 5 manipulates T-helper cells depending on its load with siderophore-bound iron.

The major cow milk allergen Bos d 5 manipulates T-helper cells depending on its load with siderophore-bound iron.

The mechanisms of allergic sensitization to milk are still elusive. The major allergen Bos d 5 belongs to the lipocalin-family and thus is able to transport numerous ligands. In this study we investigated its ability to bind to iron-siderophore complexes and tested the immune-modulatory properties o...

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Bibliographic Details
Main Authors: Franziska Roth-Walter, Luis F Pacios, Cristina Gomez-Casado, Gerlinde Hofstetter, Georg A Roth, Josef Singer, Araceli Diaz-Perales, Erika Jensen-Jarolim
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4130594?pdf=render

Internet

http://europepmc.org/articles/PMC4130594?pdf=render

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