Oxidative modifications, mitochondrial dysfunction, and impaired protein degradation in Parkinson's disease: how neurons are lost in the Bermuda triangle

<p>Abstract</p> <p>While numerous hypotheses have been proposed to explain the molecular mechanisms underlying the pathogenesis of neurodegenerative diseases, the theory of oxidative stress has received considerable support. Although many correlations have been established and enco...

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Bibliographic Details
Main Authors: Malkus Kristen A, Tsika Elpida, Ischiropoulos Harry
Format: Article
Language:English
Published: BMC 2009-06-01
Series:Molecular Neurodegeneration
Online Access:http://www.molecularneurodegeneration.com/content/4/1/24