αO-Conotoxin GeXIVA Inhibits the Growth of Breast Cancer Cells via Interaction with α9 Nicotine Acetylcholine Receptors

αO-Conotoxin GeXIVA Inhibits the Growth of Breast Cancer Cells via Interaction with α9 Nicotine Acetylcholine Receptors

The α9-containing nicotinic acetylcholine receptor (nAChR) is increasingly emerging as a new tumor target owing to its high expression specificity in breast cancer. αO-Conotoxin GeXIVA is a potent antagonist of α9α10 nAChR. Nevertheless, the anti-tumor effect of GeXIVA on breast cancer cells remains...

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Bibliographic Details
Main Authors: Zhihua Sun, Jiaolin Bao, Manqi Zhangsun, Shuai Dong, Dongting Zhangsun, Sulan Luo
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Marine Drugs
Subjects:
α9-nicotinic acetylcholine receptors (nAChRs)
breast cancer cells
αO-conotoxin GeXIVA
apoptosis
anti-proliferation
targeted therapy
Online Access:https://www.mdpi.com/1660-3397/18/4/195

Internet

https://www.mdpi.com/1660-3397/18/4/195

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