Differential Effect of Viable Versus Necrotic Neutrophils on Mycobacterium tuberculosis Growth and Cytokine Induction in Whole Blood

Neutrophils exert both positive and negative influences on the host response to tuberculosis, but the mechanisms by which these differential effects are mediated are unknown. We studied the impact of live and dead neutrophils on the control of Mycobacterium tuberculosis using a whole blood biolumine...

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Bibliographic Details
Main Authors: David M. Lowe, Julie Demaret, Nonzwakazi Bangani, Justine K. Nakiwala, Rene Goliath, Katalin A. Wilkinson, Robert J. Wilkinson, Adrian R. Martineau
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Immunology
Subjects:
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00903/full