Trans-Ancestral Fine-Mapping and Epigenetic Annotation as Tools to Delineate Functionally Relevant Risk Alleles at <i>IKZF1</i> and <i>IKZF3</i> in Systemic Lupus Erythematosus

Trans-Ancestral Fine-Mapping and Epigenetic Annotation as Tools to Delineate Functionally Relevant Risk Alleles at <i>IKZF1</i> and <i>IKZF3</i> in Systemic Lupus Erythematosus

<b>Background:</b> Prioritizing tag-SNPs carried on extended risk haplotypes at susceptibility loci for common disease is a challenge. <b>Methods:</b> We utilized trans-ancestral exclusion mapping to reduce risk haplotypes at <i>IKZF1</i> and <i>IKZF3</i&...

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Bibliographic Details
Main Authors: Timothy J. Vyse, Deborah S. Cunninghame Graham
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:International Journal of Molecular Sciences
Subjects:
trans-ancestral fine-mapping
Systemic Lupus Erythematosus
epigenetics
functional annotation
Online Access:https://www.mdpi.com/1422-0067/21/21/8383

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https://www.mdpi.com/1422-0067/21/21/8383

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