Transcriptome Analysis of CCR9+ T Helper Cells From Primary Sjögren’s Syndrome Patients Identifies CCL5 as a Novel Effector Molecule

Transcriptome Analysis of CCR9+ T Helper Cells From Primary Sjögren’s Syndrome Patients Identifies CCL5 as a Novel Effector Molecule

IntroductionCCR9+ Tfh-like pathogenic T helper (Th) cells are elevated in patients with primary Sjögren’s syndrome (pSS) and indicated to play a role in pSS immunopathology. Here we delineate the CCR9+ Th cell-specific transcriptome to study the molecular dysregulation of these cells in pSS patients...

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Bibliographic Details
Main Authors: Anneline C. Hinrichs, Sofie L. M. Blokland, Ana P. Lopes, Catharina G. K. Wichers, Aike A. Kruize, Aridaman Pandit, Timothy R. D. J. Radstake, Joel A. G. van Roon
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Immunology
Subjects:
Primary Sjögren’s syndrome
CCR9+ Th cells
transcriptomics
autoimmunity
CCL5
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.702733/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.702733/full

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