Atypical E2Fs either Counteract or Cooperate with RB during Tumorigenesis Depending on Tissue Context

Atypical E2Fs either Counteract or Cooperate with RB during Tumorigenesis Depending on Tissue Context

E2F-transcription factors activate many genes involved in cell cycle progression, DNA repair, and apoptosis. Hence, E2F-dependent transcription must be tightly regulated to prevent tumorigenesis, and therefore metazoan cells possess multiple E2F regulation mechanisms. The best-known is the Retinobla...

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Bibliographic Details
Main Authors: Eva Moreno, Shusil K. Pandit, Mathilda J. M. Toussaint, Laura Bongiovanni, Liesbeth Harkema, Saskia C. van Essen, Elsbeth A. van Liere, Bart Westendorp, Alain de Bruin
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Cancers
Subjects:
atypical E2Fs
Rb
interaction
tumorigenesis
transgenic mice
Online Access:https://www.mdpi.com/2072-6694/13/9/2033

Internet

https://www.mdpi.com/2072-6694/13/9/2033

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