Longitudinal Circulating Tumor DNA Analysis in Blood and Saliva for Prediction of Response to Osimertinib and Disease Progression in EGFR-Mutant Lung Adenocarcinoma

Longitudinal Circulating Tumor DNA Analysis in Blood and Saliva for Prediction of Response to Osimertinib and Disease Progression in EGFR-Mutant Lung Adenocarcinoma

<i>Background</i>: We assessed whether serial ctDNA monitoring of plasma and saliva predicts response and resistance to osimertinib in EGFR-mutant lung adenocarcinoma. Three ctDNA technologies—blood-based droplet-digital PCR (ddPCR), next-generation sequencing (NGS), and saliva-based EFI...

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Bibliographic Details
Main Authors: Chul Kim, Liqiang Xi, Constance M. Cultraro, Fang Wei, Gregory Jones, Jordan Cheng, Ahmad Shafiei, Trinh Hoc-Tran Pham, Nitin Roper, Elizabeth Akoth, Azam Ghafoor, Vikram Misra, Nina Monkash, Charles Strom, Michael Tu, Wei Liao, David Chia, Clive Morris, Seth M. Steinberg, Hadi Bagheri, David T. W. Wong, Mark Raffeld, Udayan Guha
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Cancers
Subjects:
ctDNA
EGFR
osimertinib
NSCLC
Online Access:https://www.mdpi.com/2072-6694/13/13/3342

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https://www.mdpi.com/2072-6694/13/13/3342

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