New Sorafenib Derivatives: Synthesis, Antiproliferative Activity Against Tumour Cell Lines and Antimetabolic Evaluation

New Sorafenib Derivatives: Synthesis, Antiproliferative Activity Against Tumour Cell Lines and Antimetabolic Evaluation

Sorafenib is a relatively new cytostatic drug approved for the treatment of renal cell and hepatocellular carcinoma. In this report we describe the synthesis of sorafenib derivatives 4a–e which differ from sorafenib in their amide part. A 4-step synthetic pathway includes preparation of 4-chloropyri...

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Bibliographic Details
Main Authors: Branka Zorc, Jos Vanderleyden, Marijeta Kralj, Mariya Petrova, Jan Balzarini, Ana-Matea Mikecin, Zrinka Rajić, Maja Crkvenčić, Željka Babić
Format: Article
Language:English
Published: MDPI AG 2012-01-01
Series:Molecules
Subjects:
sorafenib
amides
cytostatic activity
antimetabolic activity
Caco-2 cells permeability
Online Access:http://www.mdpi.com/1420-3049/17/1/1124/

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http://www.mdpi.com/1420-3049/17/1/1124/

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