Indoxyl sulfate downregulates expression of Mas receptor via OAT3/AhR/Stat3 pathway in proximal tubular cells.

Indoxyl sulfate downregulates expression of Mas receptor via OAT3/AhR/Stat3 pathway in proximal tubular cells.

Renin-angiotensin system (RAS) plays a pivotal role in chronic kidney disease (CKD). Angiotensin converting enzyme-related carboxypeptidase 2 (ACE2)/angiotensin (Ang)-(1-7)/Mas receptor axis counteracts the deleterious actions of Ang II. ACE2 exerts its actions by cleaving Ang II into Ang-(1-7) whic...

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Bibliographic Details
Main Authors: Hwee-Yeong Ng, Maimaiti Yisireyili, Shinichi Saito, Chien-Te Lee, Yelixiati Adelibieke, Fuyuhiko Nishijima, Toshimitsu Niwa
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3948887?pdf=render

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http://europepmc.org/articles/PMC3948887?pdf=render

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