N-Methyl-N-Nitrosourea-Induced Photoreceptor Degeneration Is Inhibited by Nicotinamide via the Blockade of Upstream Events before the Phosphorylation of Signalling Proteins

N-Methyl-N-Nitrosourea-Induced Photoreceptor Degeneration Is Inhibited by Nicotinamide via the Blockade of Upstream Events before the Phosphorylation of Signalling Proteins

N-methyl-N-nitrosourea (MNU), a known carcinogen, is generally used in animal models to chemically induce photoreceptor degeneration. It has been reported that nicotinamide (NAM) exerts a protective effect on MNU-induced photoreceptor degeneration. We investigated the molecular mechanisms on MNU-ind...

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Bibliographic Details
Main Authors: Eriko Sugano, Kitako Tabata, Tsubasa Takezawa, Raki Shiraiwa, Hiroki Muraoka, Tomomi Metoki, Asaka Kudo, Yuki Iwama, Mitsuru Nakazawa, Hiroshi Tomita
Format: Article
Language:English
Published: Hindawi Limited 2019-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2019/3238719

Internet

http://dx.doi.org/10.1155/2019/3238719

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