Post-stroke angiotensin II type 2 receptor activation provides long-term neuroprotection in aged rats.

Post-stroke angiotensin II type 2 receptor activation provides long-term neuroprotection in aged rats.

Activation of the angiotensin II type 2 receptor (AT2R) by administration of Compound 21 (C21), a selective AT2R agonist, induces neuroprotection in models of ischemic stroke in young adult animals. The mechanisms of this neuroprotective action are varied, and may include direct and indirect effects...

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Bibliographic Details
Main Authors: Douglas M Bennion, Jacob D Isenberg, Allison T Harmel, Kelly DeMars, Alex N Dang, Chad H Jones, Megan E Pignataro, Justin T Graham, U Muscha Steckelings, Jon C Alexander, Marcelo Febo, Eric G Krause, Annette D de Kloet, Eduardo Candelario-Jalil, Colin Sumners
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5495490?pdf=render

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http://europepmc.org/articles/PMC5495490?pdf=render

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