USP12 translocation maintains interferon antiviral efficacy by inhibiting CBP acetyltransferase activity.

USP12 translocation maintains interferon antiviral efficacy by inhibiting CBP acetyltransferase activity.

CREB-binding protein (CBP) participates in numerous transcription events. However, cell-intrinsic inhibitors of CBP are poorly defined. Here, we found that cellular USP12 interacts with the HAT domain of CBP and inhibits CBP's acetyltransferase activity. Interestingly, USP12 positively regulate...

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Bibliographic Details
Main Authors: Jin Liu, Lincong Jin, Xiangjie Chen, Yukang Yuan, Yibo Zuo, Ying Miao, Qian Feng, Hongguang Zhang, Fan Huang, Tingting Guo, Liting Zhang, Li Zhu, Feng Qian, Chuanwu Zhu, Hui Zheng
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1008215

Internet

https://doi.org/10.1371/journal.ppat.1008215

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