Erlotinib protests against LPS-induced parthanatos through inhibiting macrophage surface TLR4 expression

Abstract Sepsis is a life-threatening cascading systemic inflammatory response syndrome on account of serve infection. In inflamed tissues, activated macrophages generate large amounts of inflammatory cytokines reactive species, and are exposed to the damaging effects of reactive species. However, c...

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Bibliographic Details
Main Authors: Qiong Xue, Xiaolei Liu, Cuiping Chen, Xuedi Zhang, Pengyun Xie, Yupin Liu, Shuangnan Zhou, Jing Tang
Format: Article
Language:English
Published: Nature Publishing Group 2021-07-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-021-00571-4