Platelets promote breast cancer cell MCF-7 metastasis by direct interaction: surface integrin α2β1-contacting-mediated activation of Wnt-β-catenin pathway

Platelets promote breast cancer cell MCF-7 metastasis by direct interaction: surface integrin α2β1-contacting-mediated activation of Wnt-β-catenin pathway

Abstract Background Integrin-mediated platelet-tumor cell contacting plays an important role in promoting epithelial-mesenchymal transition (EMT) transformation of tumor cells and cancer metastasis, but whether it occurs in breast cancer cells is not completely clear. Objective The purpose of this s...

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Bibliographic Details
Main Authors: Xiao-xiao Zuo, Ya Yang, Yue Zhang, Zhi-gang Zhang, Xiao-fei Wang, Yong-gang Shi
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Cell Communication and Signaling
Subjects:
Epithelial-mesenchymal transition
Platelet
Direct interaction
MCF-7 cell
Wnt-β-catenin
TGF-β1
Online Access:http://link.springer.com/article/10.1186/s12964-019-0464-x

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http://link.springer.com/article/10.1186/s12964-019-0464-x

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