Detection and quantification of mitochondrial DNA deletions from next-generation sequence data
Abstract Background Chromosomal deletions represent an important class of human genetic variation. Various methods have been developed to mine “next-generation” sequencing (NGS) data to detect deletions and quantify their clonal abundances. These methods have focused almost exclusively on the nuclea...
Main Authors: | , , , |
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Format: | Article |
Language: | English |
Published: |
BMC
2017-10-01
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Series: | BMC Bioinformatics |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s12859-017-1821-7 |