Human-Like Neutralizing Antibodies Protect Mice from Aerosol Exposure with Western Equine Encephalitis Virus

Human-Like Neutralizing Antibodies Protect Mice from Aerosol Exposure with Western Equine Encephalitis Virus

Western equine encephalitis virus (WEEV) causes symptoms in humans ranging from mild febrile illness to life-threatening encephalitis, and no human medical countermeasures are licensed. A previous study demonstrated that immune serum from vaccinated mice protected against lethal WEEV infection, sugg...

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Bibliographic Details
Main Authors: Crystal W. Burke, Jeffrey W. Froude, Sebastian Miethe, Birgit Hülseweh, Michael Hust, Pamela J. Glass
Format: Article
Language:English
Published: MDPI AG 2018-03-01
Series:Viruses
Subjects:
western equine encephalitis virus (WEEV)
alphavirus
monoclonal antibody (mAb)
scFv-Fc
NHP antibodies
passive vaccine
aerosol challenge
antibody engineering
Online Access:http://www.mdpi.com/1999-4915/10/4/147

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http://www.mdpi.com/1999-4915/10/4/147

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