Heparanase Promotes Syndecan-1 Expression to Mediate Fibrillar Collagen and Mammographic Density in Human Breast Tissue Cultured ex vivo

Heparanase Promotes Syndecan-1 Expression to Mediate Fibrillar Collagen and Mammographic Density in Human Breast Tissue Cultured ex vivo

Mammographic density (MD) is a strong and independent factor for breast cancer (BC) risk and is increasingly associated with BC progression. We have previously shown in mice that high MD, which is characterized by the preponderance of a fibrous stroma, facilitates BC xenograft growth and metastasis....

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Bibliographic Details
Main Authors: Xuan Huang, Gina Reye, Konstantin I. Momot, Tony Blick, Thomas Lloyd, Wayne D. Tilley, Theresa E. Hickey, Cameron E. Snell, Rachel K. Okolicsanyi, Larisa M. Haupt, Vito Ferro, Erik W. Thompson, Honor J. Hugo
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
mammographic density
breast cancer
heparanase
syndecan-1
NMR
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00599/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2020.00599/full

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