Combined Dynamic Light Scattering and Raman Spectroscopy Approach for Characterizing the Aggregation of Therapeutic Proteins

Combined Dynamic Light Scattering and Raman Spectroscopy Approach for Characterizing the Aggregation of Therapeutic Proteins

Determination of the physicochemical properties of protein therapeutics and their aggregates is critical for developing formulations that enhance product efficacy, stability, safety and manufacturability. Analytical challenges are compounded for materials: (1) that are formulated at high concentrati...

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Bibliographic Details
Main Authors: E. Neil Lewis, Wei Qi, Linda H. Kidder, Samiul Amin, Stacy M. Kenyon, Steven Blake
Format: Article
Language:English
Published: MDPI AG 2014-12-01
Series:Molecules
Subjects:
dynamic light scattering
Raman spectroscopy
lysozyme
protein aggregation
self-assembly
Online Access:http://www.mdpi.com/1420-3049/19/12/20888

Internet

http://www.mdpi.com/1420-3049/19/12/20888

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