Munc18-1 catalyzes neuronal SNARE assembly by templating SNARE association

Munc18-1 catalyzes neuronal SNARE assembly by templating SNARE association

Sec1/Munc18-family (SM) proteins are required for SNARE-mediated membrane fusion, but their mechanism(s) of action remain controversial. Using single-molecule force spectroscopy, we found that the SM protein Munc18-1 catalyzes step-wise zippering of three synaptic SNAREs (syntaxin, VAMP2, and SNAP-2...

Full description

Bibliographic Details
Main Authors: Junyi Jiao, Mengze He, Sarah A Port, Richard W Baker, Yonggang Xu, Hong Qu, Yujian Xiong, Yukun Wang, Huaizhou Jin, Travis J Eisemann, Frederick M Hughson, Yongli Zhang
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-12-01
Series:eLife
Subjects:
Sec1/Munc18 (SM) proteins
SNARE proteins
SNARE assembly
optical tweezers
template complex
membrane fusion
Online Access:https://elifesciences.org/articles/41771

Internet

https://elifesciences.org/articles/41771

Similar Items