Oxidative DNA Damage, Inflammatory Signature, and Altered Erythrocytes Properties in Diamond-Blackfan Anemia

Oxidative DNA Damage, Inflammatory Signature, and Altered Erythrocytes Properties in Diamond-Blackfan Anemia

Molecular pathophysiology of Diamond-Blackfan anemia (DBA) involves disrupted erythroid-lineage proliferation, differentiation and apoptosis; with the activation of p53 considered as a key component. Recently, oxidative stress was proposed to play an important role in DBA pathophysiology as well. CR...

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Bibliographic Details
Main Authors: Katarina Kapralova, Ondrej Jahoda, Pavla Koralkova, Jan Gursky, Lucie Lanikova, Dagmar Pospisilova, Vladimir Divoky, Monika Horvathova
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:International Journal of Molecular Sciences
Subjects:
Diamond-Blackfan anemia
reactive oxygen species
8-oxoguanine
DNA damage response
inflammatory cytokines
erythrocyte lifespan
Online Access:https://www.mdpi.com/1422-0067/21/24/9652

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https://www.mdpi.com/1422-0067/21/24/9652

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