A SOCS1/3 antagonist peptide protects mice against lethal infection with influenza A virus

A SOCS1/3 antagonist peptide protects mice against lethal infection with influenza A virus

We have developed an antagonist to suppressor of cytokine signaling 1 (SOCS1), pJAK2(1001-1013), that corresponds to the activation loop of the Janus kinase JAK2, which is the binding site for the kinase inhibitory region (KIR) of SOCS1. Internalized pJAK2(1001-1013) inhibits SOCS1 and SOCS3. SOCS...

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Bibliographic Details
Main Authors: Chulbul M. Ahmed, Rea eDabelic, Simone Kennedy Bedoya, Joseph eLarkin, Howard M Johnson
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-11-01
Series:Frontiers in Immunology
Subjects:
Influenza A virus
antivirals
innate immune response
SOCS
SOCS antagonist
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00574/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00574/full

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