Thiosemicarbazide Derivatives Decrease the ATPase Activity of <i>Staphylococcus aureus</i> Topoisomerase IV, Inhibit Mycobacterial Growth, and Affect Replication in <i>Mycobacterium smegmatis</i>

Thiosemicarbazide Derivatives Decrease the ATPase Activity of <i>Staphylococcus aureus</i> Topoisomerase IV, Inhibit Mycobacterial Growth, and Affect Replication in <i>Mycobacterium smegmatis</i>

Compounds targeting bacterial topoisomerases are of interest for the development of antibacterial agents. Our previous studies culminated in the synthesis and characterization of small-molecular weight thiosemicarbazides as the initial prototypes of a novel class of gyrase and topoisomerase IV inhib...

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Bibliographic Details
Main Authors: Aleksandra Kowalczyk, Agata Paneth, Damian Trojanowski, Piotr Paneth, Jolanta Zakrzewska-Czerwińska, Paweł Stączek
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
thiosemicarbazides
antibacterial agents
molecular modelling
bacterial type IIA topoisomerases
DNA replication
time-lapse microfluidic microscopy
Online Access:https://www.mdpi.com/1422-0067/22/8/3881

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https://www.mdpi.com/1422-0067/22/8/3881

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