Synthesis of (<em>R</em>) and (<em>S</em>)-3-Chloro-5-(2,4-dimethylpiperazin-1-yl)-4<em>H</em>-1,2,6-thiadiazin-4-one

Synthesis of (<em>R</em>) and (<em>S</em>)-3-Chloro-5-(2,4-dimethylpiperazin-1-yl)-4<em>H</em>-1,2,6-thiadiazin-4-one

The reaction of 3,5-dichloro-4<i>H</i>-1,2,6-thiadiazin-4-one with (<i>R</i>) and (<i>S</i>)-1,3-dimethylpiperazine (1 equiv), in THF, at ca. 20 °C gives (<i>R</i>) and (<i>S</i>)-3-chloro-5-(2,4-dimethylpiperazin-1-yl)-4<i>H</i>...

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Bibliographic Details
Main Authors: Andreas S. Kalogirou, Christopher R. M. Asquith, Panayiotis A. Koutentis
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Molbank
Subjects:
substitution
heterocycle
thiadiazine
piperazine
chirality
Online Access:https://www.mdpi.com/1422-8599/2020/2/M1139

Internet

https://www.mdpi.com/1422-8599/2020/2/M1139

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