Crosstalk between the muscular estrogen receptor α and BDNF/TrkB signaling alleviates metabolic syndrome via 7,8-dihydroxyflavone in female mice

Crosstalk between the muscular estrogen receptor α and BDNF/TrkB signaling alleviates metabolic syndrome via 7,8-dihydroxyflavone in female mice

Objective: 7,8-Dihydroxyflavone (7,8-DHF), a small molecular mimetic of brain-derived neurotrophic factor (BDNF), alleviates high-fat diet-induced obesity in female mice in a sex-specific manner by activating muscular tropomyosin-related kinase B (TrkB). However, the underlying molecular mechanism f...

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Bibliographic Details
Main Authors: Zhenlei Zhao, Fan Xue, Yanpei Gu, Jianxin Han, Yingxian Jia, Keqiang Ye, Ying Zhang
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Molecular Metabolism
Subjects:
7,8-dihydroxyflavone
Metabolic syndrome
Hypothalamic-pituitary-ovarian axis
Estrogen receptor α
BDNF/TrkB signaling pathway
Menopause
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877820302234

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http://www.sciencedirect.com/science/article/pii/S2212877820302234

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